Caries experience in children and adolescents with Down Syndrome: A systematic review and meta-analysis.

AIM: This study aimed to perform a systematic review and meta-analysis comparing the prevalence of dental caries in non-syndromic children with children and adolescents with Down syndrome (DS). METHODS: The strategy included a search for articles in electronic databases (MEDLINE via PubMed, Cochrane Library, LILACS, and SciELO). The methods for assessment included the modified Newcastle-Ottawa scale, the methodological quality for cross-sectional studies, and a random-effects meta-analysis model. By obtaining the odds ratio, the tests of heterogeneity and sensitivity were performed. This study includes unpublished data from the cross-sectional study by Paiva et al. (2018), which was conducted in the city of Recife/PE. RESULTS: Twelve cross- section studies met the eligibility criteria and were included in the meta-analysis. Results indicated that children and adolescents with DS had lower caries experience when compared to the non-syndromic ones (95 % CI: 0.22-0.84). The results indicated that the seven studies were statistically significant (p < 0.00001). The risk of bias remained high given that the majority of the studies were cross-sectional reports. CONCLUSION: The results of this study fill the lack of knowledge and indicated that there is scientific evidence to suggest that children and adolescents with Down Syndrome have fewer caries than the non-syndromic group.

Dental development in children born to Zikv-infected mothers: a case-based study.

BACKGROUND: In Brazil, in October 2015, an outbreak of Zika virus (ZIKV) infection and an increase in newborns with microcephaly suggested a relationship between maternal infection and microcephaly in children. OBJECTIVE: First, to assess the presence of dental bud sin 13 infants with a confirmed diagnosis of congenital ZIKV syndrome, born to mothers infected with the virus during pregnancy; second, to evaluate the dental development of these children at a 36-month follow-up. DESIGN: Case-based longitudinal study. RESULTS: Dental radiographs in the first semester showed that all children had dental buds. Along with the study, the individuals presented with various dental disturbances. At the end of the evaluation period, some children still had incomplete deciduous dentition. CONCLUSION: The abnormal chronology of dental eruption and dental development disturbances in children with microcephaly infected with ZIKV born to infected mothers indicate a possible role of the virus in odontogenesis.

Existe associação entre manchas de esmalte em pré-molares e tratamento endodôntico nos seus antecessores decíduos? / Is there an association between enamel stains in premolars and endodontic treatment of their primary molar predecessors?

Objetivo: este estudo longitudinal retrospectivo objetivou avaliar se existe relação entre o surgimento de manchas de esmalte em pré-molares, após o tratamento endodôntico dos seus antecessores molares decíduos.Métodos: as crianças submetidas à pesquisa, pacientes do Instituto de Medicina Integral Professor Fernando Figueira (IMIP), desde a mais tenra idade, foram localizados, juntamente com seus prontuários, e agrupados igualmente em três grupos conforme avaliação: (1) pré-molares sucessores de dentes decíduos que foram submetidos ao tratamento endodôntico com sessão única de Formocresol; (2) pré-molares sucessores de dentes decíduos que foram submetidos ao tratamento endodôntico com CTZ; (3) pré-molares cujos molares decíduos antecessores não possuíam lesões de acometimento pulpar. Um único examinador, com o intuito de identificar manchas de esmalte, avaliou 180 pré-molares, sem conhecimento prévio do histórico clínico ao qual foram submetidos seus antecessores decíduos,utilizando inspeção visual conferindo um índice Cohen´s kappa = 0,90. O teste de Qui-quadrado de Person e o exato de Fisher foram utilizados para identificar as diferenças entre os grupos experimentais e entre os grupos experimentais e o controle, respectivamente, em relação ao surgimento de manchas. O nível de significância adotado nesse estudo foi de 5%. Resultados: foi identificado que 8,3% dos pré-molares tratados com Formocresol e 11,7% tratados com o CTZ apresentaram algum tipo de mancha no esmalte (p>0.05), no entanto, não foram detectadas manchas nos dentes do grupo controle (p<0.05). Conclusão: quando os dentes antecessores decíduos foram submetidos à terapia endodôntico com Formocresol ou CTZ, houve surgimento de manchas em pré-molares, não havendo, no entanto, diferença estatisticamente significante...

Objective: The aim of this longitudinal retrospective study was to investigate whether there is association of the presence of enamel stains in premolars after endodontic treatment of their primary molar predecessors. Method: The children of this research have been patients of the Integral Medicine Institute Professor Fernando Figueira (IMIP) since their earliest age. The children were localized, their clinical charts were retrieved, and three groups were formed according to the evaluation: (1) successor premolars of primary molars subjected to single-session endodontic treatment with formocresol; (2) successor premolars of primary molars subjected to endodontic treatment with CTZ paste; and (3) successor premolars of primary molars that had no previous pulp involvement. A single examiner blinded to the clinical history of the primary molar predecessors evaluated 180 premolars for enamel stains by visual inspection, with a Cohen?s index kappa=0.90. Pearson?s square chi and Fisher?s exact tests were used to identify the differences among the experimental groups, and between the control and experimental groups, respectively, as regards the presence of enamel stains. The significance level was set at 5%. Results: 8.3% of the premolars that had the primary molar predecessors treated with formocresol and 11.7% of those treated with CTZ had some kind of enamel stain (p>0.05). There were no enamel stains in the teeth of the control group (p less than 0.05). Conclusion: When the primary molar predecessors were subjected to endodontic treatment with both formocresol and CTZ, enamel stains developed in the premolars, though without statistically significant difference...